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What type of standards to use with an FTIR for raw material ID?

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Probiotics10215

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Posted 01 November 2017 - 09:39 PM

My company has recently acquired an FTIR for incoming raw material identification.  I am looking to get reference standards for some of our ingredients, but I am running in to the argument of USP standards verses reagent or ACS standards.  We have about 500 different incoming raw materials so USP reference standards will be costly.  Is it necessary from an FDA standpoint to obtain USP standards for raw materials or would reagent grade or ACS grade work as well? Would FTIR spectra be noticeably different using an USP verses a ACS grade?  We are not using HPLC or GC, this is to collect spectra for an in house library, also only using qualitatively. Also we fall into the dietary supplement category, so we are not making pharmaceuticals.



Charles.C

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Posted 02 November 2017 - 02:25 AM

My company has recently acquired an FTIR for incoming raw material identification.  I am looking to get reference standards for some of our ingredients, but I am running in to the argument of USP standards verses reagent or ACS standards.  We have about 500 different incoming raw materials so USP reference standards will be costly.  Is it necessary from an FDA standpoint to obtain USP standards for raw materials or would reagent grade or ACS grade work as well? Would FTIR spectra be noticeably different using an USP verses a ACS grade?  We are not using HPLC or GC, this is to collect spectra for an in house library, also only using qualitatively. Also we fall into the dietary supplement category, so we are not making pharmaceuticals.

 

Hi Probiotics,

 

Plesdse add a little context, eg 

 

FTIR = ?

 

Example of one of the ingredients  = ?


Kind Regards,

 

Charles.C


Probiotics10215

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Posted 02 November 2017 - 01:30 PM

The FTIR is an Aglient Cary 630 with an ATR.  Materials are pretty much anything from vitamins, minerals, sugars,and peptone.  Common ingredients are dextrose, ascorbic acid, potassium phosphate, calcium carbonate, methyl paraben, and sodium acetate.  We have other ingredients which customers supply us or are ingredients that I don't know what they are made of. I have found many spectra online from NIST, but obviously the resolution is not as clear when comparing them to the online spectra. 



Charles.C

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Posted 03 November 2017 - 01:59 AM

The FTIR is an Aglient Cary 630 with an ATR.  Materials are pretty much anything from vitamins, minerals, sugars,and peptone.  Common ingredients are dextrose, ascorbic acid, potassium phosphate, calcium carbonate, methyl paraben, and sodium acetate.  We have other ingredients which customers supply us or are ingredients that I don't know what they are made of. I have found many spectra online from NIST, but obviously the resolution is not as clear when comparing them to the online spectra. 

 

Hi pro,

 

Thks but FTIR = ?

 

and ATR = ?

 

Acronyms are convenient but .......

 

I somehow anticipate that IR = infra-red.


Kind Regards,

 

Charles.C


Charles.C

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Posted 03 November 2017 - 02:05 AM

addendum

 

apparently FT = Fourier Transform

 

ATR = attenuated total reflection

 

Offhand (no experience of FTIR-ATR), yr OP looks like a good question to test the instrument supplier.


Kind Regards,

 

Charles.C




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