Micro challenge testing
Dear everybody,
I am writing to ask about micro challenge testing.
Could you help me with guidline for this
I appreciate your helps a lot
Dear everybody,
I am writing to ask about micro challenge testing.
Could you help me with guidline for this
I appreciate your helps a lot
Hi akool,
This is a very wide subject.
Do you have any particular area of interest/application ?
Hi akool,
This is a very wide subject.
Do you have any particular area of interest/application ?
Dear Charles C,
Thank you for your precious response
My Japan customer ask for Microbio challenge testing activities in Lab. The framework include:
-Selection of pathogen or surrogate
-Level of challenge inoculum
-Duration of the study
-Formulation factors and processing condition
-Sample analyses and calculation of log reduction
-Interpretation of the data
-Pass / fail criteria & Recommendations
I wondering if there is any standard (ISO , AOAC, .....etc) for these activities and there is any guideline for these mentioned above
I wish you and everyone here who work with microbio challenge testing can help me
Sincerely yours.
Dear Charles C,
Thank you for your precious response
My Japan customer ask for Microbio challenge testing activities in Lab. The framework include:
-Selection of pathogen or surrogate
-Level of challenge inoculum
-Duration of the study
-Formulation factors and processing condition
-Sample analyses and calculation of log reduction
-Interpretation of the data
-Pass / fail criteria & Recommendations
I wondering if there is any standard (ISO , AOAC, .....etc) for these activities and there is any guideline for these mentioned above
I wish you and everyone here who work with microbio challenge testing can help me
Sincerely yours.
Hi akool,
Thks for details.
I am wondering why yr customer is asking for this info.
IMEX routine, in-plant labs infrequently perform such testing unless there is a specific necessity. Commercial analytical services do offer such facilities, eg
https://www.leatherh...llenge-testing/
http://www.merieuxnu...nge-studies/548
A detailed example of the theoretical/practical factors involved is attached -
challenge testing of micro,safety of raw milk cheeses,2011.pdf 1.92MB 21 downloads
and one more -
micro.challenge testing for L.monocytogenes,2014.pdf 579.49KB 25 downloads
It depends. Is your process and product unique? If not, you will likely find the regulatory or peer-reviewed documentation to support the validation of your process and product.
For example, we produce milk in the US. Our validation for the milk processing/pasteurization is the FDA pasteurization time and temperature limits. All we do is reference that standard to validate.
Your process could be that simple.
Hi akool,
Thks for details.
I am wondering why yr customer is asking for this info.
IMEX routine, in-plant labs infrequently perform such testing unless there is a specific necessity. Commercial analytical services do offer such facilities, eg
https://www.leatherh...llenge-testing/
http://www.merieuxnu...nge-studies/548
A detailed example of the theoretical/practical factors involved is attached -
challenge testing of micro,safety of raw milk cheeses,2011.pdf
and one more -
It depends. Is your process and product unique? If not, you will likely find the regulatory or peer-reviewed documentation to support the validation of your process and product.
For example, we produce milk in the US. Our validation for the milk processing/pasteurization is the FDA pasteurization time and temperature limits. All we do is reference that standard to validate.
Your process could be that simple.
Now i validate shelf life using durability .
So, are durability study and challenge testing independent?