6 replies to this topic

[Yoloooo]

Hi All ,

My company has over 1500 raw ingredients ( sugars , corn syrup, supplements, vitamins etc)
We need to start doing identity on all of them … however to send each sample to a lab for identity it is impossible- we will get broke!
How to do identity on sugar , corn syrup etc ?
And how to go about rest of the ingredients?

[Scampi]

confused what your asking

 

Do you currently get a Certificate of Conformity or Analysis with each lot?  That's where I'd start

[Yoloooo]

Yes of course . But if you check the FDA regulations all the material that is being received must be checked for identity.

And I am wondering how to go about it

[kingstudruler1]

I think this question was asked last week.  FTIR or similar would seem to be a operator friendly & diverse solution.

 

I'd contact an instrument manufacture and ask about their solutions for your application.   Thermo, bruker, shimadzu, perkin elmer, etc.  You may need more than one technology.   

[Yoloooo]

Hi , thanks . Yes I know that I need instruments .

Does anyone knows how to do identity on sugars , corn stupors etc ?

[kingstudruler1]

perhaps the same answer.  FTIR, polarimetry, hplc, ect.   Depends on the sugar / syrup you are interested in as there are many.   

 

On the ASSAY portion of your coa, TDS, etc,  it should give you test methods that they are using to determine purity or concentrations.   Thats a good starting point as well.   

[matthewcc]

My answer would depend on whether you are in the United States.  FDA won't let you use FT-IR for dietary ingredient identity except in very limited, rigorous uses.

 

You have to identify 100% of the ingredients you receive in the US [https://www.federalr...-operations-for], but first, you have to start establishing identity specifications [https://www.ecfr.gov/current/title-21/part-111#p-111.70(b)(1)].  

 

For your question about how to do the testing, I would start with the ones FDA requires in https://www.ecfr.gov...-111.75(h)--i.e., gross organoleptic analysis; macroscopic analysis; microscopic analysis; chemical analysis; or other scientifically valid methods.  Organoleptic analysis might be the easiest, but by itself, it will not be adequate unless you have enough specificity to identify it and distinguish it from other substances.  Maybe the best instrumental method would be to use HPTLC for many of these.  The ingredients you mentioned strongly suggest HPTLC would be a good technique.  If you don't have an instrument, you might want to check it out.  Keep reference standards of materials whenever possible, preferably ones that are highly characterized and from a third-party supplier with lots of documentation. 

 

Good luck, as this is a very large task.

 

Matthew