in principle GMO are not a hazard as long as the GMO a registered.
Here you are looking for a unintended contamination. So, if you are asking for statements you have to be aware on the legislation (in the EU 1829/2004 and 1830/2004) and you have to talk on detection limits, the possible events and have to get informations on the supply chain. We have created 4 GMO risk classes for our raw materials.
For risk classes 3 and 4 we have special requirements incl. monitoring. For risk class 4 we get an CoA with delivery and do own monitoring test 4x/y.
Thank you for your response.
I assume risk category 1 & 2 are both low risk. What's the difference between risk 1 and risk 2 category ingredients. Can you please tell a couple of example. Thank you
I can provide some examples. But this is not simply transferable to others because it is based on our individual situation (company policies, data systems in place, type of raw material, some general rules (don't from ... (supplier x, country, traders etc.),history, experiences).
We always try to build 4 risk classes (microbial, chemical, physical, finished products, GMO...) which helps in the daily business (release of...; set up of monitoring programs)
With GMO the principle is to follow the supply chain, where ever possible with docs (e.g. soy IP).
Definition of classes with examples:
Highly processed raw materials in which no or hardly any plant DNA is found (solvents such as ethanol, carriers such as triacetin or glycerine, oils etc.)
- analysis not useful. -> Class I is not routinely analysed.
Critical GMO raw materials which are not authorised and not used in the country of origin of the raw material
(e.g. source rice from Italy instead of...)
Critical GMO raw materials which are almost unprocessed or only mechanically treated parts of a plant (e.g. flours).
In the case of chemical treatment stages, the distinction to Class I must be clarified.
Delivery with special GMO-CoA (ervery x batches)
Critical GMO raw materials which are known to be used in the country of origin in addition to the non-GMO variant (soy lecithin from Brazil).
This class also includes raw materials with a low content of critical GMO raw materials (e.g. chocolates with a soya lecithin content of 0.5%)
Each delivery with special GMO-CoA and supply chain docs.
No acceptance of levels of contanimation of registered events > 0,1%. Zero tolerance for non regstered.
This can only be the frame and is not carved in stone. Often you have take individual case decision. In some cases I have done "supported raw material batch releases for our supplier e.g for soy lecithin which should become of part a composed raw material delivered to us (only for the GMO-part, not in general).
For sampling and testing (supplier or monitoring) we have defined parameters (methods, events). Data sourcing on registered events per country, applied GMO per country and monitoring of recalls for non authorized events (per country -> don't buy in....)
Coming back to the beginning. Overall there is a complex system of informations around the examples and class building.
And now CRISPR/Cas.....